Development of Tizanidine HCl transdermal patches: In-vitro and Ex-vivo characterization
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چکیده
منابع مشابه
Development of domperidone bilayered matrix type transdermal patches: physicochemical, in vitro and ex vivo characterization
BACKGROUND AND THE PURPOSE OF THE STUDY Domperidone (DOM) is a dopamine- receptor (D(2)) antagonist, which is widely used in the treatment of motion-sickness. The pharmacokinetic parameters make DOM a suitable candidate for transdermal delivery. The purpose of the present investigation was to develop transdermal delivery systems for DOM and to evaluate their physicochemical characteristics, in ...
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The purpose of the study was to develop Tizanidine HCl (TZN) and Meloxicam (MLX) loaded bilayer mucoadhesive films intended for buccal administration, aiming to enhance the bioavailability. Bilayer films were prepared by solvent evaporation technique selecting arabinoxylan (ARX) as a sustained release (SR) layer forming polymer and hydroxypropyl methylcellulose (HPMC) E-15 as an immediate relea...
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The unidirectional release buccal patches of carbamazepine (CBZ) were designed in total of 36 formulations using a 32 full factorial design. Different hydrophilic polymers were used in the formulation along with chitosan-HPMC matrix. The thickness of the prepared patches varied between 0.3 ± 0.10 and 0.5 ± 0.15 mm. The mass of the patches varied from 142.4 ± 0.22 and 160.2 ± 0.13 mg. The pH of ...
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2019
ISSN: 2250-1177
DOI: 10.22270/jddt.v9i1-s.2431